Angol orvosi véleményben segitetek? Bővebben lent.

Külföldön tartozkodom, megcsináltattam egy tesztet ahol levélben küldték a kiértékelést.Pajzsmirigy problémám van valoszinüleg.A forditok rosszul forditják, angolul jól tudók segitségét megköszönném, röviden ha leirnák mi a lényege a szövegnek.

Lab Comments

Cortisol is within normal range in the morning and at noon, but rises to a high level in the evening and high-normal at night.

Higher evening/night cortisol indicates either some form of adrenal stressor(s) that is increasing adrenal gland synthesis of

cortisol or supplementation with a glucocorticoid (eg. hydrocortisone used as an anti-inflammatory or some other cortisol

analogue used for treating allergies or asthma) or adrenal adaptogen that increases adrenal cortisol synthesis (eg. herbal

medications such as licorice or ginseng), The most common stressors include: psychological stressors (emotional), physical

insults (injury, pain, diseases), chemical exposure (environmental pollutants, excessive medications), hypoglycemia (low blood

sugar), and pathogenic infections (bacterial, viral, fungal). Acute situational stressors (e.g., anxiety over unresolved situations,

coming home from work to a stressful situation.) can also result in a transient increase in evening/night cortisol levels, which is a

normal response to the stressor. Chronic high evening/night cortisol is commonly associated with sleep disturbances, fatigue,

depression, weight gain in the waist, bone loss, and anxiety. This condition can also impair the actions of other hormones such

as insulin and thyroid, causing symptoms of their deficiency, even though the levels of these hormones may be within normal

range (i.e., insulin resistance and thyroid deficiency). For additional information about strategies for supporting adrenal health

and reducing stressors, the following books are worth reading: "Adrenal Fatigue", by James L. Wilson, N.D., D.C., Ph.D.; "The

Cortisol Connection", by Shawn Talbott, Ph.D.; "The End of Stress As We Know It" by Bruce McEwen; "Awakening Athena" by

Kenna Stephenson, MD.

Estradiol (blood spot) is lower than the observed range for a premenopausal woman during the luteal phase of the menstrual

cycle. This could indicate anovulation during this cycle (more common as menopause approaches with irregular menstrual

cycles), collection of blood during early follicular phase of the cycle, use of a hormonal contraceptive (none indicated-lowers

ovarian synthesis of estradiol, progesterone, and testosterone), use of herbs containing high levels of phytoestrogens, or, in rare

cases, ovarian failure (confirmed with high FSH).

Progesterone (blood spot) is within expected low end of the range for a premenopausal woman during mid-luteal phase of the

menstrual cycle. Progesterone should be well balanced with estradiol (optimal Pg/E2 ratio 100-500, when estradiol is within

mid-physiological range).

Testosterone (blood spot) is within normal range but symptoms of androgen deficiency persist. This may be due to other

hormonal imbalances with symptom profiles similar to low androgens, which include low thyroid or low cortisol caused by

excessive stressors. Note that symptoms of both low thyroid and low cortisol are self-reported as problematic.

DHEAS (blood spot) is within high-normal range. DHEAS is highest during the late teens to early twenties and then declines

progressively with age to the lower levels of the range in healthy men and women. DHEAS is expected to be within the lower

range in older individuals. Higher DHEAS levels in individuals older than 40 is usually associated with DHEA supplementation,

but is not uncommon in well trained atheletes. High DHEAS can be associated with symptoms of androgen excess (e.g. loss of

scalp hair, increased facial/body hair, acne).

SHBG is within normal range. The SHBG level is a relative index of overall exposure to all forms of estrogens (endogenous,

pharmaceutical, xeno-estrogens). As the estrogen levels increase in the bloodstream there is a proportional increase in hepatic

production of SHBG. Thyroid hormone and insulin also play a role in regulating hepatic SHBG synthesis. Thyroid hormone

synergizes with estrogen to increase SHGB production while insulin, in excess (caused by insulin resistance) decreases SHGB

synthesis. Thus, in individuals with thyroid deficiency and insulin resistance the SHBG level is usually low. SHBG is an important

estradiol and testosterone binding globulin that help increase the half life of these hormones in the bloodstream, and also limit

their bioavailability to target tissues. SHBG binds tightly to testosterone and its more potent metabolite dihydrotestosterone

(DHT). It also binds tightly to estradiol, the most potent of the endogenous estrogens, but about 5 times weaker than to

testosterone and DHT. Thus an increase in SHBG results in proportionately less bioavailable testosterone than estradiol.

Free T4 is within normal range.

Free T3, the most potent bioactive thyroid hormone, is low-normal and TSH is high, indicating a clinically hypothyroid state.

Normal T4 and low T3 usually results from poor hepatic conversion of T4 to T3, which suggests one or more of the following:

nutrient deficiency (e.g., zinc and/or selenium), heavy metal toxicity (mercury, lead, cadmium), liver damage (caused by viruses,

alcohol, etc.), or steroid hormone imbalances (e.g., high cortisol). Testing for steroid hormones (estradiol, progesterone,

testosterone, DHEAS, cortisol am/pm) also is worthwhile considering. Stress and associated high cortisol, can cause mineral

deficiencies (zinc and selenium) important for liver conversion of T4 to T3. If conventional T4 therapy does not resolve

symptoms of thyroid deficiency, consider combination T4/T3 replacement therapy or slow release T3 therapy alone. Because

thyroid replacement increases the degradation rate of cortisol in the liver it is important that cortisol levels are within normal range

before thyroid therapy is considered. Otherwise, thyroid therapy may further exacerbate low cortisol symptoms (hypoglycemia,

sugar craving, and fatigue-tired but wired feeling) and, in turn, compromise the actions of thyroid, which require normal

physiological levels of cortisol.

Thyroid peroxidase antibodies (TPO) are low indicating that Hashimoto's thyroiditis is unlikely.